Advancing microengineered models to replicate human physiology and guide future therapies.

Biomimetic Organ Systems

In my research group, we aim to advance our ability to replicate the complexity of human tissues and organs by employing biologically inspired design principles alongside cutting-edge engineering strategies. Our goal is to use these advanced microphysiological systems to investigate human physiological responses in extreme and difficult-to-study environments.

Research Thrust 1: Engineering multiscale structural orders to unveil early reproductive and developmental challenges.

Advancements in reproductive medicine, particularly in vitro fertilization, have enhanced our understanding of early embryonic life. However, the complexities of implantation and subsequent developmental stages remain insufficiently explored. Key challenges include the poor understanding of implantation processes and the impact of maternal factors, such as malnutrition and endocrine disruptors, on embryogenesis. My research program involves employing cutting-edge stem cell bioengineering strategies and organ-on-chip technologies to explore maternal health effects on early-stage pregnancy. These methods allow for controlled studies of interactions influencing embryo implantation and growth. This research program aims to uncover the relationships between maternal conditions and fetal development, providing insights that can inform better strategies for enhancing reproductive health and improving fetal outcomes.

Research Thrust 2: Exploring pathogens and their role in infectious diseases: leveraging tissue-engineered 3D models array for precision studies.

Microorganisms, ranging from beneficial microbes to harmful pathogens, play a crucial role in human health by influencing immune responses, metabolic processes, and disease outcomes. Recent pandemics underscore the complexity of interactions between harmful pathogens and human tissues, particularly for emerging infectious diseases. Our current understanding of these relationships remains limited, hindering our ability to effectively prevent and treat such threats. Additionally, individual susceptibility to pathogens can vary widely, influenced by factors such as genetics, underlying health conditions, lifestyle, and environmental exposures. To develop effective prevention and treatment strategies, understanding the complex relationships between pathogens and human tissues is essential. To address this challenge, we will utilize a tissue-engineered 3D model array, which offers a promising approach for studying these interactions in a controlled and realistic environment. These three-dimensional cultures can replicate the human immune response and tissue architecture, allowing researchers to investigate pathogens interactions and their impact on health with greater precision.

Research Thrust 3: Microengineered human organoids-on-chips for assessing environmental and toxicological effects on human health.

Human health is constantly shaped by the environments we inhabit and the various toxicological exposures we face. From air and water pollution to chemical contaminants and radiation, these environmental factors pose significant risks to both short- and long-term health. Studying the interactions between various environmental stressors and biological systems are intricate and not fully understood, therefore having an enhanced in vitro model capable of replicating human physiology and the complexity of environmental interactions will further better assess human responses to toxicological exposures and devise strategies to reduce their impact on public health. Cutting-edge models, such as organ-on-a-chip and organoids, provide new avenues to study interactions between environmental stressors and human health in a controlled, physiologically relevant manner. By leveraging the best of these two technologies and creating innovative platforms, we can better assess human responses to toxicological exposures and devise strategies to reduce their impact on public health.

Strategic Path Forward